Roles of mRNA poly (A) tails in regulation of eukaryotic gene expression

LA Passmore, J Coller - Nature Reviews Molecular Cell Biology, 2022 - nature.com
… binding to poly(A) RNA, facilitating PABPC multimerization 47 . … Before an mRNA can be
degraded, its poly(A) tail is removed … TTP binds to AU-rich elements (AREs) in the mRNA 3ʹ …

Poly (A) tale: From A to A; RNA polyadenylation in prokaryotes and eukaryotes

A Mofayezi, M Jadaliha, F Zangeneh… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
… Finally, because partially degraded mRNAs are unable to … M gene, leading to removal of
the last exon which codes for … and facilitates circularization of c-fos mRNA by engaging poly(…

Structural basis for the recognition of transiently structured AU-rich elements by Roquin

O Binas, JN Tants, SA Peter, R Janowski… - Nucleic Acids …, 2020 - academic.oup.com
degradation (6–9). In line with that, aberrantly expressed transcripts of tumor-promoting
transcription factors like c-fos … these RBPs by removing their ssRNA target sites in the 3′-UTR, …

CPEB and translational control by cytoplasmic polyadenylation: impact on synaptic plasticity, learning, and memory

YS Huang, R Mendez, M Fernandez, JD Richter - Molecular Psychiatry, 2023 - nature.com
AU-rich elements (AREs) [20], the ability to (re)-elongate the … blot is due to poly(A) lengthening,
removal of poly(A) by oligo(… For example, CPEB4-activated c-Fos translation occurs only …

Host poly (A) polymerases PAPD5 and PAPD7 provide two layers of protection that ensure the integrity and stability of hepatitis B virus RNA

F Liu, ACH Lee, F Guo, AS Kondratowicz… - Journal of …, 2021 - Am Soc Microbiol
… FIG 3 AB-452 promotes HBV RNA degradation through … and poly(A) tail integrity, knockout
(KO) cell lines with deletion of … sequence facilitates the addition of G while extending the …

RNA-binding proteins in regulating mRNA stability and translation: roles and mechanisms in cancer

W Li, X Deng, J Chen - Seminars in cancer biology, 2022 - Elsevier
… /2/3) often facilitate the mRNA stability and translation process … ) and AU-rich element RBP
1 (AUF1), which induce the rapid … Decapping enzymes impel degradation by removing the cap …

RNA binding proteins Smaug and Cup induce CCR4–NOT-dependent deadenylation of the nanos mRNA in a reconstituted system

F Pekovic, C Rammelt, J Kubíková, J Metz… - Nucleic acids …, 2023 - academic.oup.com
… Smaug also induces nos mRNA degradation during the first … The NOT10 sequence was
removed from its vector with KpnI … on the substrate, PABPC facilitates further deadenylation. …

Basis of gene structure and function

SM Farrow - Molecular Endocrinology, 2020 - taylorfrancis.com
… factors preventing or facilitating access of RNases to the 3'-UTR… It seems likely that the effects
of AU-rich sequences on mRNA … ) Removal of poly(A) and consequent degradation of c-fos

[HTML][HTML] Protein binding to Cis-Motifs in mRNAs coding sequence is common and regulates transcript stability and the rate of translation

EA Grzybowska, M Wakula - Cells, 2021 - mdpi.com
… The most known is probably RBP binding to AU-rich … the case of c-fos mRNA, where
destabilization of mRNA occurs in … [52], but the removal of CDS m6A from methylated transcripts …

[图书][B] Poly (A) Tail Regulation in the Nucleus

J Alles - 2022 - search.proquest.com
… ’-end, which protects them from degradation and stimulates … the branch point sequence and
facilitates recruitment of the U5-… deletion of AUrich sequence elements (AREs) from the c-Fos